Col1a1^{tm1(tetO-URI1)Ndj}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-URI1)Ndj}
• Name: collagen, type I, alpha 1; targeted mutation 1, Nabil Djouder
• MGI ID: MGI:5706755
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-URI1)Ndj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217463
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-URI1)Ndj} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  URI1 (8725)

  Uri1	(MGI:1342294)

• Mutation details: A construct containing an FRT site, tetO sequence, FLAG tagged human URI1 cDNA, and FRT site was inserted via RMCE in KH2 ES cells carrying the allele Col1a1^{tm13(neo/hygro*)Jae} . (J:217463)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

Notes

This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

• Original: J:217463 Tummala KS, et al., Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 2014 Dec 8;26(6):826-39
• All: 4 reference(s)