Uri1^tm1.1Ndj
Targeted Allele Detail

Summary

• Symbol: Uri1^tm1.1Ndj
• Name: URI1, prefoldin-like chaperone; targeted mutation 1.1, Nabil Djouder
• MGI ID: MGI:5706757
• Gene: Uri1 Location: Chr7:37659417-37722976 bp, - strand Genetic Position: Chr7, 25.29 cM
• Alliance: Uri1^tm1.1Ndj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217463
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:217463)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uri1 Mutation: 72 strains or lines available

References

• Original: J:217463 Tummala KS, et al., Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 2014 Dec 8;26(6):826-39
• All: 4 reference(s)