Senp2^tm1Eyeh
Targeted Allele Detail

Summary

• Symbol: Senp2^tm1Eyeh
• Name: SUMO/sentrin specific peptidase 2; targeted mutation 1, Edward TH Yeh
• MGI ID: MGI:5706831
• Synonyms: SENP2^fxN
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^tm1Eyeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217910
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 13 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 14 via homologous recombination. Real-time PCR and western blot analysis indicates a significant reduction in expression in the brain and heart of homozygous mice. (J:217910)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 51 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Sudden unexplained death in epilepsy J:217910.

References

• Original: J:217910 Qi Y, et al., Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 3;83(5):1159-71
• All: 1 reference(s)