Senp2^tm1.1Eyeh
Targeted Allele Detail

Summary

• Symbol: Senp2^tm1.1Eyeh
• Name: SUMO/sentrin specific peptidase 2; targeted mutation 1.1, Edward TH Yeh
• MGI ID: MGI:5706833
• Synonyms: SENP2^fx
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^tm1.1Eyeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217910
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 13 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 14 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:217910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 51 strains or lines available

References

• Original: J:217910 Qi Y, et al., Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 3;83(5):1159-71
• All: 3 reference(s)