Dusp5^tm1.1Skey
Targeted Allele Detail

Summary

• Symbol: Dusp5^tm1.1Skey
• Name: dual specificity phosphatase 5; targeted mutation 1.1, Stephen M Keyse
• MGI ID: MGI:5706846
• Gene: Dusp5 Location: Chr19:53517576-53530240 bp, + strand Genetic Position: Chr19, 47.98 cM
• Alliance: Dusp5^tm1.1Skey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216939
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:216939)

Tumor Data

List all tumor models in MMHCdb carrying Dusp5^tm1.1Skey

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp5 Mutation: 16 strains or lines available

References

• Original: J:216939 Rushworth LK, et al., Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72
• All: 3 reference(s)