Tg(Alb-MYLIP*)1Pton
Transgene Detail

Summary

• Symbol: Tg(Alb-MYLIP*)1Pton
• Name: transgene insertion 1, Peter Tontonoz
• MGI ID: MGI:5706928
• Synonyms: L-sIDOL
• Transgene: Tg(Alb-MYLIP*)1Pton Location: unknown
• Alliance: Tg(Alb-MYLIP*)1Pton page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Alb-MYLIP*)1Pton expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYLIP (29116)

  Mylip

  (MGI:2388271)

• Mutation details: A degradation-resistant, dominant-active form of human MYLIP/IDOL carrying K293R, K309R, K310R, and K320R mutations is expressed under the direction of the mouse albumin enhancer/promoter and followed by bovine growth hormone polyA. (J:228420)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:228420 Calkin AC, et al., Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circ Res. 2014 Aug 1;115(4):442-9
• All: 2 reference(s)