Phf24^{tm1.2(HBEGF)Azmo}
Targeted Allele Detail

Summary

• Symbol: Phf24^{tm1.2(HBEGF)Azmo}
• Name: PHD finger protein 24; targeted mutation 1.2, Aziz Moqrich
• MGI ID: MGI:5706936
• Synonyms: GINIP^mcherry
• Gene: Phf24 Location: Chr4:42916660-42944752 bp, + strand Genetic Position: Chr4, 22.91 cM
• Alliance: Phf24^{tm1.2(HBEGF)Azmo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Phf24^{tm1.2(HBEGF)Azmo} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Exons 1 and 2 were replaced with a floxed stop cassette, human diptheria toxin receptor (HBEGF) gene, IRES, mCherry reporter and an FRT flanked neo cassette via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed the floxed stop cassette. (J:218052)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf24 Mutation: 27 strains or lines available

References

• Original: J:218052 Gaillard S, et al., GINIP, a Galphai-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Neuron. 2014 Oct 1;84(1):123-36
• All: 1 reference(s)