Dusp5^tm1.1Achn
Targeted Allele Detail

Summary

• Symbol: Dusp5^tm1.1Achn
• Name: dual specificity phosphatase 5; targeted mutation 1.1, Andrew C Chan
• MGI ID: MGI:5706941
• Gene: Dusp5 Location: Chr19:53517576-53530240 bp, + strand Genetic Position: Chr19, 47.98 cM
• Alliance: Dusp5^tm1.1Achn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218203
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 1 and a loxP site was inserted downstream of exon 1 via homologous recombination. Cre-mediated recombination removed the neo cassette and exon 1. Western blot analysis confirmed the absence of protein expression in activated CD4+ T cells. (J:218203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp5 Mutation: 16 strains or lines available

References

• Original: J:218203 Holmes DA, et al., Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J. 2015 Jan 14;34(2):218-35
• All: 1 reference(s)