Chrnb2^tm1.1Cont
Targeted Allele Detail

Summary

• Symbol: Chrnb2^tm1.1Cont
• Name: cholinergic receptor nicotinic beta 2 subunit; targeted mutation 1.1, Anis Contractor
• MGI ID: MGI:5707003
• Synonyms: beta2^V287L
• Gene: Chrnb2 Location: Chr3:89660755-89671939 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Chrnb2^tm1.1Cont page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228269
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 3 was replaced with one in which a point mutation results in the amino acid substitution of leucine for valine at position 287 (V287L). Cre-mediated recombination removed the floxed neomycin selection inserted downstream of the modified exon. (J:228269)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrnb2 Mutation: 32 strains or lines available

References

• Original: J:228269 Xu J, et al., Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the beta2 nicotinic receptor. Mol Psychiatry. 2011 Oct;16(10):1048-61
• All: 1 reference(s)