Helz2^tm1Tesa
Targeted Allele Detail

Summary

• Symbol: Helz2^tm1Tesa
• Name: helicase with zinc finger 2, transcriptional coactivator; targeted mutation 1, Tetsurou Satoh
• MGI ID: MGI:5707023
• Gene: Helz2 Location: Chr2:180869408-180883820 bp, - strand Genetic Position: Chr2, 103.63 cM
• Alliance: Helz2^tm1Tesa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including exons 1-6 was replaced with a neo cassette via homologous recombination. Northern blot and immunohistochemical analysis confirmed the absence of mRNA and protein expression in livers from homozygous mice. (J:218127)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Helz2 Mutation: 140 strains or lines available

References

• Original: J:218127 Yoshino S, et al., Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Endocrinology. 2014 Sep;155(9):3459-72
• All: 1 reference(s)