Lonp1^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Lonp1^tm1Otin
• Name: lon peptidase 1, mitochondrial; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:5707160
• Gene: Lonp1 Location: Chr17:56921297-56933887 bp, - strand Genetic Position: Chr17, 29.42 cM, cytoband D
• Alliance: Lonp1^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A beta-geo cassette replaced exons 2-4. (J:221992)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lonp1 Mutation: 40 strains or lines available

References

• Original: J:221992 Quiros PM, et al., ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Cell Rep. 2014 Jul 24;8(2):542-56
• All: 2 reference(s)