Ntrk3^{tm3.1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Ntrk3^{tm3.1(cre/ERT2)Ddg}
• Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 3.1, David D Ginty
• MGI ID: MGI:5707203
• Synonyms: TrkC^CreER
• Gene: Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
• Alliance: Ntrk3^{tm3.1(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227979
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Ntrk3^{tm3.1(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk3 (MGI:97385)

• Mutation details: An indicible cre recombinase gene (cre/ERT2) and an FRT-flanked neomycin resistance cassette were inserted at the translation initiation site replacing the coding sequence in exon 1. Flp-mediated recombination removed the selection cassette. (J:227979)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk3 (mouse) Summary of all recombinase alleles driven by Ntrk3. Comparative matrix view of recombinase activities Alliance mouse Ntrk3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk3 Mutation: 67 strains or lines available

References

• Original: J:227979 Bai L, et al., Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell. 2015 Dec 17;163(7):1783-95
• All: 14 reference(s)