Esrp1^tm1.2Rpc
Targeted Allele Detail

Summary

• Symbol: Esrp1^tm1.2Rpc
• Name: epithelial splicing regulatory protein 1; targeted mutation 1.2, Russ P Carstens
• MGI ID: MGI:5707244
• Gene: Esrp1 Location: Chr4:11331933-11386783 bp, - strand Genetic Position: Chr4, 5.11 cM
• Alliance: Esrp1^tm1.2Rpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226997
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 6 upstream of exon 7, a neomycin selection cassette flanked by FRT sites in intron 9 followed by a loxP site. The neomycin cassette and exons 7-9 were removed via cre-mediated recombination. Excision of exons 7-9 removes the first RNA Recognition Motif and places the remaining transcript out of frame, generating a null allele. (J:226997)

Expression

In Mice Carrying this Mutation:	73 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esrp1 Mutation: 19 strains or lines available

References

• Original: J:226997 Bebee TW, et al., The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4
• All: 7 reference(s)