Wee1^tm1.1Cxd
Targeted Allele Detail

Summary

• Symbol: Wee1^tm1.1Cxd
• Name: WEE 1 homolog 1 (S. pombe); targeted mutation 1.1, Chu-Xia Deng
• MGI ID: MGI:5707453
• Gene: Wee1 Location: Chr7:109721266-109742506 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Wee1^tm1.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228492
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 9. A floxed neomycin resistance cassette was inserted downsteam of exon 10. Cre-mediated recombination removed exons 9 through 10 and the selection cassette. (J:228492)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wee1 Mutation: 37 strains or lines available

References

• Original: J:228492 Tominaga Y, et al., Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci. 2006;2(4):161-70
• All: 2 reference(s)