Plp2^tm1Dva
Targeted Allele Detail

Summary

• Symbol: Plp2^tm1Dva
• Name: proteolipid protein 2; targeted mutation 1, David Valle
• MGI ID: MGI:5707490
• Synonyms: Plp2^-
• Gene: Plp2 Location: ChrX:7534180-7537629 bp, - strand Genetic Position: ChrX, 3.45 cM, cytoband A2-A3.1
• Alliance: Plp2^tm1Dva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A LacZ-neo cassette was inserted into exon 1, six codons downstream of the translational start site. Northern blot analysis revealed absence of transcript in primary neurons isolated from hemizygous mutant males. Western blot analysis confirmed the absence of protein expression in mutant retinal tissue. (J:227053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plp2 Mutation: 7 strains or lines available

References

• Original: J:227053 Zhang L, et al., Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury. Hum Mol Genet. 2015 Dec 20;24(25):7221-6
• All: 1 reference(s)