Lep^tm1.1Gvcao
Targeted Allele Detail

Summary

• Symbol: Lep^tm1.1Gvcao
• Name: leptin; targeted mutation 1.1, Gwen Childs
• MGI ID: MGI:5707692
• Synonyms: Leptin^fl
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^tm1.1Gvcao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218720
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:218720)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 21 strains or lines available

References

• Original: J:218720 Odle AK, et al., Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin. Endocrinology. 2014 Nov;155(11):4316-28
• All: 5 reference(s)