Fmo5^tm1Eshe
Targeted Allele Detail

Summary

• Symbol: Fmo5^tm1Eshe
• Name: flavin containing monooxygenase 5; targeted mutation 1, Elizabeth A Shephard
• MGI ID: MGI:5707817
• Synonyms: Fmo5^-
• Gene: Fmo5 Location: Chr3:97536120-97562598 bp, + strand Genetic Position: Chr3, 42.23 cM
• Alliance: Fmo5^tm1Eshe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223365
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin resistance cassette. Western blot of liver proteins showed a lack of encoded protein expression in homozygous mutant mice compared with control mice. (J:223365)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmo5 Mutation: 25 strains or lines available

References

• Original: J:223365 Gonzalez Malagon SG, et al., The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochem Pharmacol. 2015 Aug 1;96(3):267-77
• All: 5 reference(s)