Dixdc1^tm1Bnrc
Targeted Allele Detail

Summary

• Symbol: Dixdc1^tm1Bnrc
• Name: DIX domain containing 1; targeted mutation 1, Benjamin Cheyette
• MGI ID: MGI:5707820
• Synonyms: Dixdc1^-, Dixdc1^neo
• Gene: Dixdc1 Location: Chr9:50574052-50650817 bp, - strand Genetic Position: Chr9, 27.75 cM, cytoband B
• Alliance: Dixdc1^tm1Bnrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222364
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons B2, 2 and 3 were replaced by a neo cassette via homologous recombination. This mutation is predicted to introduce a premature stop codon in all transcripts. Northern blot analysis of postnatal cerebral cortical lysates confirmed the absence of RNA transcript in homozygous mutant mice. (J:222364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dixdc1 Mutation: 38 strains or lines available

References

• Original: J:222364 Kivimae S, et al., Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1. Transl Psychiatry. 2011;1:e43
• All: 3 reference(s)