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Retsattm1Kpal
Targeted Allele Detail
Summary
Symbol: Retsattm1Kpal
Name: retinol saturase (all trans retinol 13,14 reductase); targeted mutation 1, Krzysztof Palczewski
MGI ID: MGI:5708113
Synonyms: RetSat-
Gene: Retsat  Location: Chr6:72575585-72584471 bp, + strand  Genetic Position: Chr6, 32.27 cM, cytoband C3
Alliance: Retsattm1Kpal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222367
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette. RT-PCR of RNA isolated from the liver of homozygous mice using primers directed against exon 1 and exon 4 shows that there was no detectable message expressed from this allele. Immunoblotting of liver lysates and immunohistochemistry of liver sections from homozygous mice indicates that the encoded protein is not detectable in homozygous mice. (J:222367)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Retsat Mutation:  23 strains or lines available
References
Original:  J:222367 Moise AR, et al., Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr;24(4):1261-70
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory