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Chchd1tm1.1(KOMP)Vlcg
Targeted Allele Detail
Summary
Symbol: Chchd1tm1.1(KOMP)Vlcg
Name: coiled-coil-helix-coiled-coil-helix domain containing 1; targeted mutation 1.1, Velocigene
MGI ID: MGI:5708199
Gene: Chchd1  Location: Chr14:20753095-20754493 bp, + strand  Genetic Position: Chr14, 11.53 cM, cytoband B
Alliance: Chchd1tm1.1(KOMP)Vlcg page
IMPC: Chchd1 gene page
Mutation
origin
Mutant Cell Line:  13426A-C2
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsCre-mediated excision of the parental Chchd1tm1(KOMP)Vlcg allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
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Source:
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IMPC - UCD
IMPC - TCP
embryo
embryonic growth retardation
abnormal embryo size
abnormal neural tube closure
pale yolk sac
growth/size/body
embryonic growth retardation
abnormal embryo size
integument
pallor
mortality/aging
preweaning lethality, complete penetrance
nervous system
abnormal neural tube closure
abnormal forebrain development
abnormal hindbrain development
abnormal midbrain development
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chchd1 Mutation:  12 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory