Mtpap^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Mtpap^{tm1.1(KOMP)Vlcg}
• Name: mitochondrial poly(A) polymerase; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5708206
• Synonyms: Mtpap^-
• Gene: Mtpap Location: Chr18:4375592-4397330 bp, + strand Genetic Position: Chr18, 2.77 cM
• Alliance: Mtpap^{tm1.1(KOMP)Vlcg} page
• IMPC: Mtpap gene page

Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 18912A-B2
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: Cre-mediated excision of the parental Mtpap^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtpap Mutation: 30 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)