Rnf213^tm1.1Kure
Targeted Allele Detail

Summary

• Symbol: Rnf213^tm1.1Kure
• Name: ring finger protein 213; targeted mutation 1.1, Shigeo Kure
• MGI ID: MGI:5708305
• Gene: Rnf213 Location: Chr11:119283926-119378244 bp, + strand Genetic Position: Chr11, 83.48 cM
• Alliance: Rnf213^tm1.1Kure page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227953
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Targeting vector was produced by cloning a loxP site into the 5' site of exon 32 and a fragment containing a FRT-flanked neomycin-resistance gene(Neo) and a loxP site into the 3' site of exon 32. Mice with germ line transmission of the targeted allele was crossed with mice expressing Flp recominase to generate mice carring the floxed allele. Offspring carrying the floxed allele were further bred with Cre recominase expressing mice to removed exon 32. (J:227953)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf213 Mutation: 192 strains or lines available

References

• Original: J:227953 Sonobe S, et al., Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease. Brain Res. 2014 Mar 13;1552:64-71
• All: 5 reference(s)