Tg(Prnp-MAPT*K274Q*K281Q)1Lgn
Transgene Detail
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Symbol: |
Tg(Prnp-MAPT*K274Q*K281Q)1Lgn |
Name: |
transgene insertion 1, Li Gan |
MGI ID: |
MGI:5708387 |
Synonyms: |
tauKQ, Tg(Prnp-MAPT*K274/K281Q)1 |
Transgene: |
Tg(Prnp-MAPT*K274Q*K281Q)1Lgn Location: unknown
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Alliance: |
Tg(Prnp-MAPT*K274Q*K281Q)1Lgn page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Tg(Prnp-MAPT*K274Q*K281Q)1Lgn expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MAPT (4137) |
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contains a K274Q and K281Q substitution (low expressor) |
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Mutation details: The transgenic construct contains a mutant human MAPT (tauKQ) transgene with lysine-to-glutamine amino acid substitutions that recapitulate MAPT K274 and K281 acetylation under the control of the mouse prion protein, Prnp, gene promoter. The nucleotide substitutions are, respectively, A to C at position 820 and A to C at position 841. Founder line 286 has higher expression of the transgene than founder line 1. The transgene is expressed in hippocampus, cortex and cerebellum.
(J:230252)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:230252 Tracy TE, et al., Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Apr 20;90(2):245-60 |
All: |
1 reference(s) |
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