Trp53^tm1.1Umol
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Umol
• Name: transformation related protein 53; targeted mutation 1.1, Ute Moll
• MGI ID: MGI:5708402
• Synonyms: p53^R248Q
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Umol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228632
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: Exons 4 through 9 were replaced with the corresponding human sequence with a mutation in exon 7 that results in the amino acid substitution of arginine with glutamine at position 248 (p.R248Q). Flp-mediated recombination removed the FRT site flanked neomycin resistance cassette inserted into intron 10. (J:228632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 239 strains or lines available

References

• Original: J:228632 Hanel W, et al., Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ. 2013 Jul;20(7):898-909
• All: 4 reference(s)