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Trp53tm2.1Umol
Targeted Allele Detail
Summary
Symbol: Trp53tm2.1Umol
Name: transformation related protein 53; targeted mutation 2.1, Ute Moll
MGI ID: MGI:5708410
Synonyms: p53G245S
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm2.1Umol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228632
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
 
Mutation detailsExons 4 through 9 were replaced with the corresponding human sequence with a mutation in exon 7 that results in the amino acid substitution of glycine with serine at position 245 (p.G245S). Flp-mediated recombination removed the FRT site flanked neomycin resistance cassette inserted into intron 10. (J:228632)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  239 strains or lines available
References
Original:  J:228632 Hanel W, et al., Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ. 2013 Jul;20(7):898-909
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory