Trp53tm2.1Umol
Targeted Allele Detail
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Symbol: |
Trp53tm2.1Umol |
Name: |
transformation related protein 53; targeted mutation 2.1, Ute Moll |
MGI ID: |
MGI:5708410 |
Synonyms: |
p53G245S |
Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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Alliance: |
Trp53tm2.1Umol page
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Germline Transmission: |
Earliest citation of germline transmission:
J:228632
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Parent Cell Line: |
iTL BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Humanized sequence) |
Mutation: |
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Insertion
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Mutation details: Exons 4 through 9 were replaced with the corresponding human sequence with a mutation in exon 7 that results in the amino acid substitution of glycine with serine at position 245 (p.G245S). Flp-mediated recombination removed the FRT site flanked neomycin resistance cassette inserted into intron 10.
(J:228632)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53 Mutation: |
239 strains or lines available
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Original: |
J:228632 Hanel W, et al., Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ. 2013 Jul;20(7):898-909 |
All: |
1 reference(s) |
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