Dao^tm1Ttsu
Targeted Allele Detail

Summary

• Symbol: Dao^tm1Ttsu
• Name: D-amino acid oxidase; targeted mutation 1, Takashi Tsukamoto
• MGI ID: MGI:5708529
• Gene: Dao Location: Chr5:114141764-114163743 bp, + strand Genetic Position: Chr5, 55.93 cM
• Alliance: Dao^tm1Ttsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228710
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1957 bp, encompassing exon 7 and 8. Western blot analysis confirmed the absence of protein expression in the cerebellum. (J:228602, J:228710)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dao Mutation: 27 strains or lines available

Notes

ES cell line = TG-ES01-01 ESM07

References

• Original: J:228710 Rais R, et al., Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metab Dispos. 2012 Nov;40(11):2067-73
• All: 4 reference(s)