Kdm6b^tm1.1Rfw
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.1Rfw
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.1, Rong-fu Wang
• MGI ID: MGI:5708545
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.1Rfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 15. An additional loxP site was inserted downstream of exon 21. Cre-mediated recombination removed the selection cassette and exons 15 through 21. (J:228713)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:228713 Zhao W, et al., Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell. 2013 Feb 28;152(5):1037-50
• All: 2 reference(s)