Ubtf^tm1.2Tmss
Targeted Allele Detail

Summary

• Symbol: Ubtf^tm1.2Tmss
• Name: upstream binding transcription factor, RNA polymerase I; targeted mutation 1.2, Tom Moss
• MGI ID: MGI:5708604
• Synonyms: Ubf^delta
• Gene: Ubtf Location: Chr11:102195386-102210568 bp, - strand Genetic Position: Chr11, 66.29 cM, cytoband D
• Alliance: Ubtf^tm1.2Tmss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228597
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 3 through 5. (J:228597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubtf Mutation: 55 strains or lines available

References

• Original: J:228597 Hamdane N, et al., Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body. PLoS Genet. 2014 Aug;10(8):e1004505
• All: 3 reference(s)