Arid1a^tm1.1Mag
Targeted Allele Detail

Summary

• Symbol: Arid1a^tm1.1Mag
• Name: AT-rich interaction domain 1A; targeted mutation 1.1, Terry Magnuson
• MGI ID: MGI:5708705
• Synonyms: Arid1a^fl
• Gene: Arid1a Location: Chr4:133406319-133484080 bp, - strand Genetic Position: Chr4, 66.25 cM
• Alliance: Arid1a^tm1.1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219794
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 5 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:219794)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid1a Mutation: 181 strains or lines available

References

• Original: J:219794 Chandler RL, et al., Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118
• All: 7 reference(s)