Mrgprb2^em1Xzd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrgprb2^em1Xzd
• Name: MAS-related GPR, member B2; endonuclease-mediated mutation 1, Xinzhong Dong
• MGI ID: MGI:5749280
• Synonyms: Mrgprb2^MUT
• Gene: Mrgprb2 Location: Chr7:48200713-48207834 bp, - strand Genetic Position: Chr7, 31.11 cM
• Alliance: Mrgprb2^em1Xzd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Targeted zinc finger nucleases generates a 4 bp deletion in the coding sequence that results in a frameshift mutation and early termination shortly after the first transmembrane domain. (J:219209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrgprb2 Mutation: 34 strains or lines available

References

• Original: J:219209 McNeil BD, et al., Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015 Mar 12;519(7542):237-41
• All: 15 reference(s)