Rbp4^{tm1(RBP4)Zhel}
Targeted Allele Detail

Summary

• Symbol: Rbp4^{tm1(RBP4)Zhel}
• Name: retinol binding protein 4, plasma; targeted mutation 1, Zhenghua Li
• MGI ID: MGI:5749289
• Synonyms: hVal30:hRBP4, mRbp4^hRBP4
• Gene: Rbp4 Location: Chr19:38105077-38113729 bp, - strand Genetic Position: Chr19, 32.75 cM, cytoband D1
• Alliance: Rbp4^{tm1(RBP4)Zhel} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220321
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, RMCE-ready)
• Mutation: Insertion
• Rbp4^{tm1(RBP4)Zhel} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RBP4 (5950)

  Rbp4	(MGI:97879)

• Mutation details: ES cells containing the Rbp4^tm2Zhel null allele that serves as an acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a wild-type human RBP4 cDNA and a FRT-flanked puromycin resistance gene flanked by a loxKMR3 and a loxP site. (J:220321, J:260683)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbp4 Mutation: 21 strains or lines available

References

• Original: J:220321 Mu Y, et al., CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci. FEBS Lett. 2015 Mar 24;589(7):849-56
• All: 2 reference(s)