Chd7^{tm2c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Chd7^{tm2c(EUCOMM)Wtsi}
• Name: chromodomain helicase DNA binding protein 7; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5749385
• Synonyms: Chd7^fl
• Gene: Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
• Alliance: Chd7^{tm2c(EUCOMM)Wtsi} page
• IMPC: Chd7 gene page

Mutation origin

• Mutant Cell Line: EPD0019_1_D07
• Germline Transmission: Earliest citation of germline transmission: J:222062
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_st0
• Mutation details: The L1L2_st0 cassette was inserted at position 8784907 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 8786002. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:222062)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd7 Mutation: 138 strains or lines available

References

• Original: J:222062 Jones KM, et al., CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus. Stem Cells. 2015 Jan;33(1):196-210
• All: 8 reference(s)