Crb3^tm1.2Lprs
Targeted Allele Detail

Summary

• Symbol: Crb3^tm1.2Lprs
• Name: crumbs family member 3; targeted mutation 1.2, Patrick Laprise
• MGI ID: MGI:5749426
• Gene: Crb3 Location: Chr17:57368583-57372920 bp, + strand Genetic Position: Chr17, 29.65 cM
• Alliance: Crb3^tm1.2Lprs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 2, a loxP site downstream of exon 2, followed by an FRT-flanked neomycin resistance (neo) cassette, and a third loxP site. Exon 2 is the first coding exon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exon 2. (J:228786)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crb3 Mutation: 10 strains or lines available

References

• Original: J:228786 Charrier LE, et al., Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep. 2015;5:17699
• All: 1 reference(s)