Cpt1a^tm1.1Pec
Targeted Allele Detail

Summary

• Symbol: Cpt1a^tm1.1Pec
• Name: carnitine palmitoyltransferase 1a, liver; targeted mutation 1.1, Peter Carmeliet
• MGI ID: MGI:5749792
• Synonyms: Cpt1a^lox
• Gene: Cpt1a Location: Chr19:3372334-3435733 bp, + strand Genetic Position: Chr19, 3.08 cM
• Alliance: Cpt1a^tm1.1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 11 and 12 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1a Mutation: 57 strains or lines available

References

• Original: J:220527 Schoors S, et al., Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature. 2015 Apr 9;520(7546):192-7
• All: 15 reference(s)