Kcnk13^em1(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnk13^em1(IMPC)H
• Name: potassium channel, subfamily K, member 13; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:5749943
• Synonyms: THIK-1 KO
• Gene: Kcnk13 Location: Chr12:99930758-100028941 bp, + strand Genetic Position: Chr12, 50.43 cM
• Alliance: Kcnk13^em1(IMPC)H page
• IMPC: Kcnk13 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR mutagenesis induced a 1 nt insertion. This introduces a frameshift mutation into the codon for amino acid 14, leading to an abolition of the hydrophobic structure that normally forms the 1st transmembrane segment of the protein. A premature stop codon is generated after amino acid 68 in the open reading frame. (J:90559, J:256020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcnk13 Mutation: 24 strains or lines available

References

• Original: J:90559 The Mammalian Genetics Unit at Harwell, Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK. Unpublished. 2004-2013
• All: 9 reference(s)