Fnip2^tm1.2Lss
Targeted Allele Detail

Summary

• Symbol: Fnip2^tm1.2Lss
• Name: folliculin interacting protein 2; targeted mutation 1.2, Laura S Schmidt
• MGI ID: MGI:5749954
• Synonyms: Fnip2^d
• Gene: Fnip2 Location: Chr3:79363281-79475103 bp, - strand Genetic Position: Chr3, 34.91 cM
• Alliance: Fnip2^tm1.2Lss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 12 and a loxP site were inserted downstream of exon 13 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 12-13. (J:220672)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fnip2 Mutation: 60 strains or lines available

References

• Original: J:220672 Hasumi H, et al., Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1624-31
• All: 1 reference(s)