Tg(Myh6-cre/ERT2/Hif1a)#Hhas
Transgene Detail

Summary

• Symbol: Tg(Myh6-cre/ERT2/Hif1a)#Hhas
• Name: transgene insertion, Hesham A Sadek
• MGI ID: MGI:5749963
• Synonyms: alphaMHC-creERT2-ODD
• Transgene: Tg(Myh6-cre/ERT2/Hif1a)#Hhas Location: unknown
• Alliance: Tg(Myh6-cre/ERT2/Hif1a)#Hhas page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen and hypoxia
• Mutation: Insertion
• Tg(Myh6-cre/ERT2/Hif1a)#Hhas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Myh6

• Mutation details: The transgene contains the Myh6 promoter that drives cardiac-specific expression of the inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:224072)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (species not specified) Summary of all recombinase alleles driven by Myh6. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:224072 Kimura W, et al., Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature. 2015 Jul 9;523(7559):226-30
• All: 2 reference(s)