Cntnap2^tm2Pele
Targeted Allele Detail

Summary

• Symbol: Cntnap2^tm2Pele
• Name: contactin associated protein-like 2; targeted mutation 2, Elior Peles
• MGI ID: MGI:5750095
• Synonyms: Caspr2-lacZ, Cntnap2^tlacz
• Gene: Cntnap2 Location: Chr6:45036995-47278330 bp, + strand Genetic Position: Chr6, 21.81 cM, cytoband B2
• Alliance: Cntnap2^tm2Pele page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229005
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 (encoding the ATG and signal sequence) of the contactin associated protein-like 2 (Cntnap2) gene with a tau-LacZ gene and a neomycin resistance (neo) cassette in reverse orientation to the gene. Western blot and immunoblot analysis of brain and sciatic nerves, respectively, confirmed that no protein was expressed in mutant mice. (J:229005)

Disease models

Expression

In Mice Carrying this Mutation:

230 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cntnap2 Mutation: 94 strains or lines available

References

• Original: J:229005 Gordon A, et al., Expression of Cntnap2 (Caspr2) in multiple levels of sensory systems. Mol Cell Neurosci. 2016 Jan;70:42-53
• All: 6 reference(s)