Flt4^{tm2.1(cre/ERT2)Sgo}
Targeted Allele Detail

Summary

• Symbol: Flt4^{tm2.1(cre/ERT2)Sgo}
• Name: FMS-like tyrosine kinase 4; targeted mutation 2.1, Sagrario Ortega
• MGI ID: MGI:5750213
• Synonyms: Vegfr3-CreER^T2
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^{tm2.1(cre/ERT2)Sgo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228184
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Flt4^{tm2.1(cre/ERT2)Sgo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Flt4 (MGI:95561)

• Mutation details: The targeting vector was constracted by inserting an IRES sequence and inducible cre recombinase gene fusion (cre/ERT2) into the 168 bs downstream of mouse Flt4 gene STOP codon on BAC RP23-445K3. Flp-mediate recombination removed the selection cassette. (J:228184, J:257380)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Flt4 (mouse) Summary of all recombinase alleles driven by Flt4. Comparative matrix view of recombinase activities Alliance mouse Flt4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 77 strains or lines available

References

• Original: J:228184 Stanczuk L, et al., cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Rep. 2015 Mar 10
• All: 22 reference(s)