Zfp36^tm2.1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36^tm2.1Pjb
• Name: zinc finger protein 36; targeted mutation 2.1, Perry J Blackshear
• MGI ID: MGI:5750624
• Synonyms: TTPdeltaARE
• Gene: Zfp36 Location: Chr7:28076208-28078680 bp, - strand Genetic Position: Chr7, 16.72 cM
• Alliance: Zfp36^tm2.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector deletes 136 bp in the 3 UTR of the gene. The vector contains a loxP site, a wild type exon 2, an FRT-flanked neomycin cassette, a second loxP site and a mutant exon 2 containing the 136 bp deletion. Cre-mediated recombination removed the wild-type exon 2 and the neomycin cassette. (J:229078)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp36 Mutation: 19 strains or lines available

References

• Original: J:229078 Patial S, et al., Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1865-70
• All: 4 reference(s)