Gt(ROSA)26Sor^{tm1(CAG-Nr2f2)Tsa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Nr2f2)Tsa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sophia Y Tsai
• MGI ID: MGI:5750673
• Synonyms: CAG-S-COUP-TFII, COUP-TFII^OE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Nr2f2)Tsa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194187
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Nr2f2)Tsa} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nr2f2 (MGI:1352452)

• Mutation details: A conditional over-expression cassette was inserted into the locus. The cassette contains a CAG promoter, floxed STOP cassette, FLAG- and myc-tagged mouse cDNA and polyadenylation sequence.

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:194187 Qin J, et al., COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature. 2013 Jan 10;493(7431):236-40
• All: 10 reference(s)