Kit^{tm1(cre/ERT2)Bzsh}
Targeted Allele Detail

Summary

• Symbol: Kit^{tm1(cre/ERT2)Bzsh}
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Bin Zhou
• MGI ID: MGI:5750790
• Synonyms: Kit-CreER
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^{tm1(cre/ERT2)Bzsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Kit^{tm1(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kit (MGI:96677)

• Mutation details: An inducible cre recombinase gene (cre/ERT2) and an FRT-flanked neomycin resistance cassette were inserted at the translation initiation site. (J:228761)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kit (mouse) Summary of all recombinase alleles driven by Kit. Comparative matrix view of recombinase activities Alliance mouse Kit gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:228761 Liu Q, et al., c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med. 2015 Aug;21(8):866-8
• All: 10 reference(s)