Tlr5^tm1.1Gewr
Targeted Allele Detail

Summary

• Symbol: Tlr5^tm1.1Gewr
• Name: toll-like receptor 5; targeted mutation 1.1, Andrew Gewirtz
• MGI ID: MGI:5750875
• Synonyms: Tlr5^flox
• Gene: Tlr5 Location: Chr1:182782353-182804010 bp, + strand Genetic Position: Chr1, 86.12 cM
• Alliance: Tlr5^tm1.1Gewr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229155
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to place a loxP site upstream of exon 4, and a frt::loxP::Neo::frt::loxP cassette inserted 211 base pairs downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:229155)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr5 Mutation: 57 strains or lines available

References

• Original: J:229155 Chassaing B, et al., Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology. 2014 Dec;147(6):1363-77.e17
• All: 2 reference(s)