Melk^tm1.1Flev
Targeted Allele Detail

Summary

• Symbol: Melk^tm1.1Flev
• Name: maternal embryonic leucine zipper kinase; targeted mutation 1, Fred Levine
• MGI ID: MGI:5750925
• Synonyms: Delta 3
• Gene: Melk Location: Chr4:44300876-44364301 bp, + strand Genetic Position: Chr4, 23.46 cM
• Alliance: Melk^tm1.1Flev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 3. The presence of a cryptic ATG codon in exon 2 results in smaller 71 kDa and 66 kDa kinase-dead variants. (J:228782)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Melk Mutation: 41 strains or lines available

References

• Original: J:228782 Chung CH, et al., Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not beta-cell, regeneration. Physiol Rep. 2014 Sep 1;2(9)
• All: 1 reference(s)