Glul^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Glul^tm1.1Geno
• Name: glutamate-ammonia ligase; targeted mutation 1.1, Genoway
• MGI ID: MGI:5750936
• Synonyms: Glul^fl
• Gene: Glul Location: Chr1:153775692-153785469 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
• Alliance: Glul^tm1.1Geno page

RNA oxidation in Glul^tm1.1Geno/Glul^tm1.1Geno Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mouse brain

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted downstream of exon 1a and an FRT flanked selection cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:221031)

Generation of the Glul^tm1.1Geno allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glul Mutation: 36 strains or lines available

References

• Original: J:221031 Qvartskhava N, et al., Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6
• All: 4 reference(s)