Grid2^ts3
Spontaneous Allele Detail

Summary

• Symbol: Grid2^ts3
• Name: glutamate receptor, ionotropic, delta 2; ts3
• MGI ID: MGI:5751064
• Gene: Grid2 Location: Chr6:63232860-64681307 bp, + strand Genetic Position: Chr6, 29.77 cM
• Alliance: Grid2^ts3 page

Grid2^ts3/Grid2^ts3 mice fall frequently and display an inability to right themselves easily

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Spontaneous (Null/knockout) Mutation: Intragenic deletion Mutation details: A spontaneous mutation in C57BL/6 mice deleted 1001 bp spanning exons 3 to 8. The resulting frame-shift mutation caused an amino acid substitution from amino acid 83 and the following amino acids until premature termination at amino acid 124. Western blot analysis using a C-terminal antibody confirmed the absence of full-length protein in the cerebella. (J:222504)

Generation of the Grid2^ts3 allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid2 Mutation: 85 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Spinocerebellar Degeneration (J:222504).

References

• Original: J:222504 Miyoshi Y, et al., A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia. PLoS One. 2014;9(9):e107867
• All: 1 reference(s)