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Grid2ts3
Spontaneous Allele Detail
Summary
Symbol: Grid2ts3
Name: glutamate receptor, ionotropic, delta 2; ts3
MGI ID: MGI:5751064
Gene: Grid2  Location: Chr6:63232860-64681307 bp, + strand  Genetic Position: Chr6, 29.77 cM
Alliance: Grid2ts3 page
Grid2ts3/Grid2ts3 mice fall frequently and display an inability to right themselves easily

Show the 8 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA spontaneous mutation in C57BL/6 mice deleted 1001 bp spanning exons 3 to 8. The resulting frame-shift mutation caused an amino acid substitution from amino acid 83 and the following amino acids until premature termination at amino acid 124. Western blot analysis using a C-terminal antibody confirmed the absence of full-length protein in the cerebella. (J:222504)
Generation of the Grid2ts3 allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grid2 Mutation:  85 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Spinocerebellar Degeneration (J:222504).
References
Original:  J:222504 Miyoshi Y, et al., A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia. PLoS One. 2014;9(9):e107867
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory