Htr2c^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm1Arte
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5751109
• Synonyms: Htr2c INI
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: The 52 bp exon complementary sequence (ECS) in intron 5 was deleted. The GU1 splice donor site cgGtatgta was also mutated to cgCtatgta. These mutations inhibit the formation of a double-stranded RNA structure and the action of the ADAR enzyme (Adenosine Deaminase Acting on RNA). (J:228775)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:228775 Bombail V, et al., Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood. Eur J Neurosci. 2014 Dec;40(11):3663-73
• All: 1 reference(s)