Esr2^tm1.1Gust
Targeted Allele Detail

Summary

• Symbol: Esr2^tm1.1Gust
• Name: estrogen receptor 2 (beta); targeted mutation 1.1, Jan-Ake Gustafsson
• MGI ID: MGI:5751115
• Synonyms: ERbeta^-, ERbeta-deltaex3
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^tm1.1Gust page

Esr2^tm1.1Gust/Esr2^tm1.1Gust mouse ovaries display more atretic follicles and less corpora lutea than wild-type mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220968
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 3. (J:220968)

Generation of the Esr2^tm1Gust and Esr2^tm1.1Gust alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 36 strains or lines available

References

• Original: J:220968 Maneix L, et al., Estrogen receptor beta exon 3-deleted mouse: The importance of non-ERE pathways in ERbeta signaling. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5135-40
• All: 1 reference(s)