Trex1^tm1.1Fwpe
Targeted Allele Detail

Summary

• Symbol: Trex1^tm1.1Fwpe
• Name: three prime repair exonuclease 1; targeted mutation 1.1, Fred W Perrino
• MGI ID: MGI:5751220
• Synonyms: TREX1^D18N
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^tm1.1Fwpe page

Autoimmune phenotype in Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220965
• Parent Cell Line: XSV1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Dominant negative) Mutations: Insertion, Nucleotide substitutions Mutation details: The coding exon and 5'UTR were replaced with sequence with a C to T mutation in the 5' UTR and a D18N mutation in the exon and a floxed neo cassette was inserted in the 3' region via homologous recombination. Cre mediated recombination removed the neo cassette. (J:220965)

Generation of the Trex1^tm1.1Fwpe allele

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 26 strains or lines available

References

• Original: J:220965 Grieves JL, et al., Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5117-22
• All: 2 reference(s)