Tg(PER3*P415A*H417R)1Ljp
Transgene Detail

Summary

• Symbol: Tg(PER3*P415A*H417R)1Ljp
• Name: transgene insertion 1, Louis Ptacek
• MGI ID: MGI:5751250
• Synonyms: hPER3-P415A/H417R-Tg
• Transgene: Tg(PER3*P415A*H417R)1Ljp Location: unknown
• Alliance: Tg(PER3*P415A*H417R)1Ljp page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PER3*P415A*H417R)1Ljp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PER3 (8863)

  Per3	(MGI:1277134)

• Mutation details: The transgenic construct contains the complete sequence of the human PER3 gene from BAC clone RP11-417D2 (CHORI). The BAC is modified by the targeted mutaton of PERC3 to contain the P415A and H417R missense mutations resulting in an amino acid substitution of proline for alanine at position 415 and histidine for arginine at position 417. These two rare variants are assocated with familial advanced sleep phase (FASP) and seasonal affective disorder (SAD). (J:229233)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:229233 Zhang L, et al., A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1536-44
• All: 1 reference(s)